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Microfluidics at IMM is dealing with the implementation of analyses in microsystems.
In order to enable a timely on-site analysis space-saving, fast, cost-saving and efficient "lab-on-a-chip" or "micro total analysis" systems are developed with the aid of microtechnology.
The implementation of analyses in microfluidic systems is predominantly allocated to two major application fields- biological and medical analytics and industrial analytics. Bioanalytics is dealing with the analysis of a variety of samples with different origin in terms of biological organisms (cells, bacteria, viruses, parasites) or their building blocks (proteins, nucleic acids, metabolites, toxins, etc.) respectively. This kind of analyses is relevant to diagnostics, environmental and food analytics as well as security issues. Industrial analytics is predominantly focusing on process control and quality assurance. In this field educts and products are tested (e.g. for purity, composition, contamination), processes are checked for side reactions (process efficiency) or physical parameters are verified (e.g. temperature, density, ageing).
Project OrGaMIR: Development of a forecast analysis tool for hazard defence in critical infrastructures (http://www-cik.uni-paderborn.de/Forschung/orgamir); funded by the Federal Ministry of Education and Research
The goal of the research project is the development of a tool that allows to determine the existing and developing contamination of the air by volatile hazardous agents in subway systems. The goal of the subproject of IMM is the development of a modular analysis platform for detection of volatile compounds and its integration into the forecast system.
Lab-on-a-Chip for sample preparation and isolation of nucleic acids
In cooperation with the Institute for Military Science (Wehrwissenschaftliches Institut) Munster a chip-based microfluidic system is under development for the fully automised sample preparation and nucleic acid isolation from aqueous air samples. Hereby a commercial available spintube-based DNA preparation kit (Fa. Molzym) is transferred into a microfluidc system. The single functionalities of the kit (concentration of bacteria, lysis, DNA purification) were first established individually on single manual modules which in the next step were then automated and finally combined into an integrated chip. In addition, IMM developed a device capable to perform the preparation fully automatic. Accordingly, a suitable heating concept, valves and pumps were identified or developed to fulfil the demands of the fluidics and biology on chip.